Genetic anticipation is a rather unusual type of genetic inheritance in which there is a progressive increase in mutation severity, that in some cases the mutation can result in a disease as it is passed along generation to generation from parents to offspring. Full mechanisms which are underlying genetic anticipation for the most part are largely unknown, but the phenomenon is associated with a type of mutation called trinucleotide repeat expansions, with other explanations suggested as being telomere shortening and nongenetic factors such as increased surveillance for symptoms and signs of a particular disorder. Trinucleotide repeats are repetitive sequences of 3 nucleotides that follow patterns of CNG where in N can be any nucleotide, which can be found in the human genome within coding and noncoding DNA sequences. Unusual structural features of trinucleotide repeat sequences are thought to make them unstable and thus prone to errors during cell division.
Journal of Regenerative Medicine JRGM is a peer-reviewed scholarly journal and aims to publish the most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc.
The Journal is using Editorial Manager System for quality in review process. Editorial Manager is an online manuscript submission, review and tracking system. Review processing is performed by the editorial board members of Journal Regenerative Medicine or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript.
Authors may submit manuscripts and track their progress through the system, hopefully to publication.
Reviewers can download manuscripts and submit their opinions to the editor. Impact factor measures the quality of the Journal. In biology, regeneration is the process of renewal, restoration, and growth that makes genomes, cells, organisms, and ecosystems resilient to natural fluctuations or events that cause disturbance or damage.
Every species is capable of regeneration, from bacteria to humans. Regeneration can either be complete where the new tissue is the same as the lost tissue or incomplete were after the necrotic tissue comes fibrosis. At its most elementary level, regeneration is mediated by the molecular processes of gene regulation.
Regeneration in biology, however, mainly refers to the morphogenic processes that characterize the phenotypic plasticity of traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states.
Above the genetic level, regeneration is fundamentally regulated by asexual cellular processes. Regeneration is different from reproduction. For example, hydra performs regeneration but reproduce by the method of budding. Related Journals of Regenerative Biology: The Journal of Regenerative Medicine.
Stem cells are undifferentiated cells, that can differentiate into specialized cells and can divide to produce more stem cells. They are found in multicellular organisms. In mammals, there are two broad types of stem cells: In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues.
In a developing embryo, stem cells can differentiate into all the specialized cells—ectoderm, endoderm, and mesoderm - but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues. Related Journals of Stem Cells: Tissue Repair and Regeneration: Tissue repair and regeneration following injury or disease are often thought to recapitulate embryonic development by using similar molecular and cellular pathways.
In addition, many embryonic tissues, such as the spinal cord, heart, and limbs, have some regenerative potential and may utilize mechanisms that can be exogenously activated in adult tissues.
For example, BMP signaling regulates nervous system development, and SMAD reactivation plays a critical role in adult nerve regeneration and repair in animal models of spinal cord injury. While similar molecular pathways are utilized during embryogenesis and adult tissue regeneration, recent reports suggest the mechanisms by which these developmental programs are reactivated and maintained may vary in adult tissues.
Adult fish and amphibians have a remarkable capacity for tissue regeneration, while mammals have a limited regenerative capacity.
Related Journals of Tissue Repair and Regeneration: Rejuvenation is a medical discipline focused on the practical reversal of the aging process.
Rejuvenation is distinct from life extension. Life extension strategies often study the causes of aging and try to oppose those causes in order to slow aging.
Rejuvenation is the reversal of aging and thus requires a different strategy, namely repair of the damage that is associated with aging or replacement of damaged tissue with new tissue.
Rejuvenation can be a means of life extension, but most life extension strategies do not involve rejuvenation. Related Journals of Rejuvenation: Molecular and Cellular Engineering uses engineering principles to understand and construct cellular and molecular circuits with useful properties.
At the molecular level, proteins can be engineered to elicit specific ligand-receptor interactions, which can then be used for the rational design of targeted drug therapies. At the cellular level, metabolic engineering can create cellular biosensors that can monitor the environment for toxins or other specific molecules.Full mechanisms which are underlying genetic anticipation for the most part are largely unknown, but the phenomenon is associated with a type of mutation called trinucleotide repeat expansions, with other explanations suggested as being telomere shortening and nongenetic factors such as increased surveillance for symptoms and signs of a.
Experts in regenerative medicine have increasingly begun to embrace the view that comprehensively repairing the damage of aging is a practical and feasible goal. Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the "process of replacing, engineering or regenerating human cells, This section may rely excessively on sources too closely associated .
Stem Cell Biology, Cell Therapy and Regenerative Medicine Cardiovascular Complications Associated with Pulmonary Hypertension and Diabetes Genetic, Genomic, Proteiomic and Bioinformatic Studies of Acute Lung Injury and Pulmonary Arterial Hypertension.
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